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- Title
The MEMPACK alpha-helical transmembrane protein structure prediction server.
- Authors
Nugent, Timothy; Ward, Sean; Jones, David T.
- Abstract
Motivation: The experimental difficulties of alpha-helical transmembrane protein structure determination make this class of protein an important target for sequence-based structure prediction tools. The MEMPACK prediction server allows users to submit a transmembrane protein sequence and returns transmembrane topology, lipid exposure, residue contacts, helix–helix interactions and helical packing arrangement predictions in both plain text and graphical formats using a number of novel machine learning-based algorithms.Availability: The server can be accessed as a new component of the PSIPRED portal by at http://bioinf.cs.ucl.ac.uk/psipred/.Contact: d.jones@cs.ucl.ac.uk; t.nugent@cs.ucl.ac.uk
- Subjects
MEMBRANE proteins; PROTEIN structure; PREDICTION models; AMINO acid sequence; MACHINE learning; ALGORITHMS; HELICES (Algebraic topology)
- Publication
Bioinformatics, 2011, Vol 27, Issue 10, p1438
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btr096