We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Unexpected high troponin T and I values in a child with hypertrophic cardiomyopathy and acute chest pain: a case report.
- Authors
Avezaath, Lisanne K van; Nijenhuis, Hessel P; Kobold, Anneke C Muller
- Abstract
Background Elevated troponin T (cTnT) and/or troponin I (cTnI) can be ascribed to multiple causes, mostly resulting from cardiac tissue damage and in lesser numbers resulting from non-cardiac related causes. The presence of macrotroponins is easily overlooked, with potentially negative consequences. Case summary This case report presents a case study of a 12-year-old child known to have MYH7 gene–associated hypertrophic cardiomyopathy with acute chest pain combined with an unexpected high cTnT and cTnI. A cardiac cause was deemed unlikely after additional investigation, as these showed no abnormalities. After consulting a laboratory specialist, it could be concluded that the high cTnT and cTnI were a result of macrotroponin complexes, a protein complex consisting of circulating protein and endogenous autoantibodies against that protein, resulting in elevated values with misguiding and uncertain clinical significance. Discussion Awareness of the existence of macrotroponins could have prevented costly diagnostics and prolonged hospital admission with grave psychological impact, especially in children.
- Publication
European Heart Journal Case Reports, 2023, Vol 7, Issue 8, p1
- ISSN
2514-2119
- Publication type
Article
- DOI
10.1093/ehjcr/ytad375