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- Title
Wnt/β-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox ®.
- Authors
D'Amico, Ramona; Cordaro, Marika; Siracusa, Rosalba; Impellizzeri, Daniela; Trovato Salinaro, Angela; Scuto, Maria; Ontario, Maria Laura; Crea, Roberto; Cuzzocrea, Salvatore; Di Paola, Rosanna; Fusco, Roberta; Calabrese, Vittorio
- Abstract
Fibromyalgia (FM) is a chronic condition characterized by persistent widespread pain that negatively affects the quality of life of patients. The WNT/β-catenin signaling pathway seems to be involved in central sensitization and different pain states. The objective of this study was to investigate the beneficial effects of a new compound called Hidrox® (HD), containing 40–50% hydroxytyrosol, in counteracting the pain associated with FM. An FM-like model was induced in rats by subcutaneous injections of reserpine (1 mg/kg) for three consecutive days. Later, HD (10 mg/kg) was administered orally to the animals for seven days. Reserpine injections induced WNT/β-catenin pathway activation, release of pro-inflammatory mediators as well as a significant increase in oxidative stress. Daily treatment with HD was able to modulate the WNT/β-catenin and Nrf2 pathways and consequently attenuate the behavioral deficits and microglia activation induced by reserpine injection. These results indicate that nutritional consumption of HD can be considered as a new therapeutic approach for human FM.
- Subjects
SUBCUTANEOUS injections; THERAPEUTICS; CELLULAR signal transduction; CHRONIC pain; NUCLEAR factor E2 related factor
- Publication
Biomedicines, 2021, Vol 9, Issue 11, p1683
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines9111683