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- Title
Biomarkers in Schizophrenia: A Brief Conceptual Consideration.
- Authors
Weickert, Cynthia S.; Weickert, Thomas W.; Pillai, Anil; Buckley, Peter F.
- Abstract
Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia.
- Subjects
BIOMARKERS; SCHIZOPHRENIA; MENTAL illness genetics; ETIOLOGY of diseases; PSYCHOSES; DIAGNOSIS
- Publication
Disease Markers, 2013, Vol 35, Issue 1, p3
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2013/510402