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- Title
The essential role of DOCK8 in humoral immunity.
- Authors
Su, Helen C.; Randall, Katrina L.; Lambe, Teresa; Goodnow, Chris C.; Cornall, Richard J.
- Abstract
The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse.
- Subjects
CYTOKINESIS; IMMUNITY; IMMUNOLOGIC memory; COMMUNICABLE diseases; IMMUNODEFICIENCY; LABORATORY mice; GERMINAL centers; ECONOMICS
- Publication
Disease Markers, 2010, Vol 29, Issue 3-4, p141
- ISSN
0278-0240
- Publication type
Article