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- Title
An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease.
- Authors
Pei, Ke; Gui, Ting; Kan, Dongfang; Feng, Huichao; Jin, Yanqiang; Yang, Ying; Zhang, Qian; Du, Ziwei; Gai, Zhibo; Wu, Jibiao; Li, Yunlun
- Abstract
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.
- Subjects
LIPID metabolism; ARACHIDONIC acid; FATTY liver; RISK assessment; CERAMIDES; DISEASE risk factors
- Publication
BioMed Research International, 2020, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2020/4020249