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- Title
Effect of dopaminergic substances on sleep/wakefulness in saline- and MPTP-treated mice.
- Authors
LALOUX, CHARLOTTE; DERAMBURE, PHILIPPE; HOUDAYER, ELISE; JACQUESSON, JEAN-MARIE; BORDET, RÉGIS; DESTÉE, ALAIN; MONACA, CHRISTELLE
- Abstract
Sleep/wakefulness (S/W) disorders are frequent in Parkinson’s disease (PD). The underlying causes have yet to be elucidated but dopaminergic neurodegenerative lesions seem to contribute to appearance of the disorders and anti-Parkinsonian medication is known to accentuate S/W problems. Hence, we reasoned that studying the acute effect of dopaminergic compounds on S/W in an animal model of PD might improve our knowledge of S/W regulation in the context of partial dopaminergic depletion. To this end, we tested the effect of levodopa (l-dopa), pergolide (a mixed D2/D1 agonist) and lisuride (a D2 agonist) on S/W recordings in MPTP-treated mice, in comparison with controls. Our results showed that dopaminergic compounds modify S/W amounts in both control and MPTP mice. Wakefulness amounts are greater in MPTP mice afterl-dopa (50 mg kg−1) and lisuride (1 mg kg−1) injections compared with control mice. Moreover, the paradoxical sleep latency was significantly longer in MPTP mice after high-dosel-dopa administration. Our observations suggest that the actions of bothl-dopa and lisuride on S/W differ slightly in MPTP mice relative to controls. Hence, MPTP-induced partial DA depletion may modulate the effect of dopaminergic compounds on S/W regulation.
- Subjects
SLEEP disorders; WAKEFULNESS; PARKINSON'S disease; DOPA; LISURIDE
- Publication
Journal of Sleep Research, 2008, Vol 17, Issue 1, p101
- ISSN
0962-1105
- Publication type
Article
- DOI
10.1111/j.1365-2869.2008.00625.x