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- Title
The protective effect of pyrroloquinoline quinone and its derivatives against carbon tetrachloride-induced liver injury of rats.
- Authors
TSUCHIDA, TOSHIHIRO; YASUYAMA, TOSHIFUMI; HIGUCHI, KIYOHIRO; WATANABE, AKIHARU; URAKAMI, TEIJI; AKAIKE, TAKAAKI; SATO, KEIZO; MAEDA, HIROSHI
- Abstract
Pyrroloquinoline quinone (PQQ) and its derivative, oxazo pyrroloquinoline (OPQ-G), protected rats from experimental liver injury induced by carbon tetrachloride (CCl4) in vivo. This effect was observed after an intraperitoneal injection of 5 mg/kg PQQ or OPQ-G, which was given twice, 10 min and 1 h before CCl4 administration. Pyrroloquinoline quinone protected primary cultured rat hepatocytes from CCl4 toxicity in vitro. This protection was most effective at a concentration of 3 μmol/L PQQ. Pyrroloquinoline quinone derivatives (oxazo pyrroloquinoline, methyl-thioethyl oxazo pyrroloquinoline and PQQ-allylester) also protected the hepatocytes from CCl4 toxicity. Pyrroloquinoline quinone and its derivatives inhibited the lucigenin-enhanced chemiluminescence from isolated hepatocytes initiated by CCl4. These results suggest that eliminating free radicals is one of the protective mechanisms of PQQ and its derivatives against CCl4-induced liver injury.
- Publication
Journal of Gastroenterology & Hepatology, 1993, Vol 8, Issue 4, p342
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/j.1440-1746.1993.tb01525.x