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- Title
A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis.
- Authors
Kojima, Yasuyuki; Mogaki, Masatoshi; Takagawa, Ryo; Ota, Ikuko; Sugita, Mitsutaka; Natori, Shiho; Hamaguchi, Yohei; Kurosawa, Haruki; Fukushima, Tadao; Masui, Hidenobu; Fukazawa, Shingo; Yamanaka, Shoji; Tsuura, Yukio; Nagahori, Kaoru
- Abstract
Follow-up colonoscopy of a 25-year-old Japanese man with ulcerative colitis (UC) who had undergone endoscopic mucosal resection twice for early colon cancers revealed the presence of a new 1.5-cm-diameter tumor in the sigmoid colon. It was diagnosed by preoperative biopsy as a poorly differentiated adenocarcinoma. Sigmoidectomy was performed, and the pathological findings revealed lymphoepithelioma-like carcinoma (LEC). In situ hybridization to detect Epstein-Barr virus (EBV)-encoded small RNAs showed positive signals in stromal lymphocytes, but weak signals in the tumor cells. The association between EBV and LEC was obscure in this case. Unlike typical UC-mediated colon cancers, the lesion was poorly differentiated, and negative for p53 signals immunohistochemically. These findings may hint at a novel mechanism of carcinogenesis in UC-mediated colorectal cancer.
- Subjects
COLON cancer; ULCERATIVE colitis; COLONOSCOPY; ADENOCARCINOMA; IN situ hybridization; EPSTEIN-Barr virus; CARCINOGENESIS
- Publication
Journal of Gastroenterology, 2007, Vol 42, Issue 2, p181
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-006-1981-0