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- Title
Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24-positive chronic hepatitis C patients.
- Authors
Shiina M; Kobayashi K; Kobayashi T; Kondo Y; Ueno Y; Shimosegawa T; Shiina, Masaaki; Kobayashi, Koju; Kobayashi, Tomoo; Kondo, Yasuteru; Ueno, Yoshiyuki; Shimosegawa, Tooru
- Abstract
<bold>Background: </bold>The cellular immune response is important in chronic hepatitis C (CHC). To better understand its mechanism, we examined dendritic cells (DCs) and hepatitis C virus (HCV)-specific cytotoxic T cells (CTLs), which are thought to contribute to liver injury and viral clearance.<bold>Methods: </bold>CHC patients received 24 weeks of interferon-alpha-based antiviral therapy. We analyzed time-sequential frequencies of peripheral DCs, classified as myeloid DCs (mDCs) or plasmacytoid DCs (pDCs), together with peptide major histocompatibility class I tetramers, epitope specific for HCV core 129-137 (t*24/c129) or HCV NS3 1296-1304 (t*24/ns1294), directly ex vivo.<bold>Results: </bold>The mDC and pDC populations changed in parallel (P < 0.05), showing a significant transient decrease at weeks 12 and 16 during the therapy, and then recovering. However, neither of the tetramer results showed a direct correlation with the kinetics of peripheral DCs.<bold>Conclusions: </bold>There is an apparent effect of antiviral therapy or a subsequent reduction of HCV on host immunity, but the effect may not include the induction of CTLs in CHC.
- Publication
Journal of Gastroenterology, 2006, Vol 41, Issue 8, p758
- ISSN
0944-1174
- Publication type
journal article
- DOI
10.1007/s00535-006-1843-9