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- Title
Reduced-intensity hematopoietic stem-cell transplantation for malignant lymphoma: a retrospective survey of 112 adult patients in Japan.
- Authors
Kusumi, E.; Kami, M.; Kanda, Y.; Murashige, N.; Kishi, Y.; Suzuki, R.; Takeuchi, K.; Tanimoto, T. E.; Mori, T.; Muta, K.; Tamaki, T.; Tanaka, Y.; Ogawa, H.; Yamane, T.; Taniguchi, S.; Takaue, Y.
- Abstract
Summary:We conducted a nation-wide survey of 112 adult Japanese patients who underwent reduced-intensity stem cell transplantation (RIST) from 1999 to 2002. Underlying diseases included indolent (n=45), aggressive (n=58) and highly aggressive lymphomas (n=9). Median age of the patients was 49 years. A total of 40 patients (36%) had relapsed diseases after autologous stem cell transplantation and 36 patients (32%) had received radiotherapy. RIST regimens were fludarabine-based (n=95), low-dose total body irradiation-based (n=6) and others (n=11). Cumulative incidences of grade II–IV acute graft-versus-host disease (GVHD) and chronic GVHD were, respectively, 49 and 59%. Cumulative incidences of progression and progression-free mortality were 18 and 25%, respectively. With a median follow-up of 23.9 months, 3-year overall survival rates were 59%. A multivariate analysis identified three significant factors for progression, which are history of radiation (relative risk (RR) 3.45, confidential interval (CI) 1.12–10.0, P=0.03), central nervous system involvement (RR 6.25, CI 2.08–20.0, P=0.001) and development of GVHD (RR 0.28, CI 0.090–0.86, P=0.026). RIST may have decreased the rate of transplant-related mortality, and GVHD may have induced a graft-versus-lymphoma effect. However, whether or not these potential benefits can be directly translated into improved patient survival should be evaluated in further studies.Bone Marrow Transplantation (2005) 36, 205–213. doi:10.1038/sj.bmt.1705027; published online 6 June 2005
- Subjects
STEM cell transplantation; HEMATOPOIETIC stem cells; GRAFT versus host disease; AUTOTRANSPLANTATION; LYMPHOPROLIFERATIVE disorders; TRANSPLANTATION immunology
- Publication
Bone Marrow Transplantation, 2005, Vol 36, Issue 3, p205
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705027