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- Title
Transition Metal‐Catalyzed Reactions and Solid‐Phase Synthesis: A Convenient Blend.
- Authors
Cornier, Patricia G.; Delpiccolo, Carina M. L.; Martiren, Nadia L.; Mata, Ernesto G.; Mendez, Luciana; Squizatto, Caterina Permingeat; Pizzio, Marianela G.
- Abstract
Transition metal‐catalyzed, C−C and C−N bond‐forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid‐phase chemistry soon made this type of reaction applicable to solid‐supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid‐phase CuAAC and ring‐closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd‐catalyzed reactions, such as Suzuki‐Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid‐phase transition metal‐catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands.
- Subjects
SOLID-phase synthesis; ORGANIC chemistry; SYNTHETIC biology; SMALL molecules; METATHESIS reactions; RING-opening reactions
- Publication
European Journal of Organic Chemistry, 2022, Vol 2022, Issue 38, p1
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.202200526