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ABCB1 and ABCG2 Control Brain Accumulation and Intestinal Disposition of the Novel ROS1/TRK/ALK Inhibitor Repotrectinib, While OATP1A/1B, ABCG2, and CYP3A Limit Its Oral Availability.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 11, p. 1761, doi. 10.3390/pharmaceutics13111761
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- Publication type:
- Article
P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 9, p. N.PAG, doi. 10.3390/ph15091124
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- Publication type:
- Article
P-Glycoprotein (ABCB1/MDR1) and BCRP (ABCG2) Limit Brain Accumulation and Cytochrome P450-3A (CYP3A) Restricts Oral Exposure of the RET Inhibitor Selpercatinib (RETEVMO).
- Published in:
- Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1087, doi. 10.3390/ph14111087
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- Publication type:
- Article
Anti-GD2 Immunoliposomes for Targeted Delivery of the Survivin Inhibitor Sepantronium Bromide (YM155) to Neuroblastoma Tumor Cells.
- Published in:
- Pharmaceutical Research, 2018, v. 35, n. 4, p. N.PAG, doi. 10.1007/s11095-018-2373-x
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- Publication type:
- Article
Brain and Testis Accumulation of Regorafenib is Restricted by Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1).
- Published in:
- Pharmaceutical Research, 2015, v. 32, n. 7, p. 2205, doi. 10.1007/s11095-014-1609-7
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- Publication type:
- Article
Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699).
- Published in:
- Pharmaceutical Research, 2015, v. 32, n. 1, p. 37, doi. 10.1007/s11095-014-1442-z
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- Publication type:
- Article
Dendrimer-Based Macromolecular Conjugate for the Kidney-Directed Delivery of a Multitargeted Sunitinib Analogue.
- Published in:
- Macromolecular Bioscience, 2012, v. 12, n. 1, p. 93, doi. 10.1002/mabi.201100277
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- Publication type:
- Article
Extrahepatic metabolism of ibrutinib.
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- Investigational New Drugs, 2021, v. 39, n. 1, p. 1, doi. 10.1007/s10637-020-00970-x
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- Publication type:
- Article
Structure elucidation of aplidine metabolites formed in vitro by human liver microsomes using triple quadrupole mass spectrometry.
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- Journal of Mass Spectrometry, 2005, v. 40, n. 6, p. 821, doi. 10.1002/jms.863
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- Publication type:
- Article
Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells.
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- International Journal of Nanomedicine, 2012, v. 7, p. 417, doi. 10.2147/IJN.S26485
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- Publication type:
- Article
Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies.
- Published in:
- Investigational New Drugs, 2012, v. 30, n. 4, p. 1557, doi. 10.1007/s10637-011-9723-4
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- Publication type:
- Article
In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug.
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- Investigational New Drugs, 2007, v. 25, n. 1, p. 9, doi. 10.1007/s10637-006-7589-7
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- Publication type:
- Article
In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis®, Trabectidin®), a novel marine anti-cancer drug.
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- Investigational New Drugs, 2006, v. 24, n. 1, p. 3, doi. 10.1007/s10637-005-4538-9
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- Publication type:
- Article
Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole.
- Published in:
- Biomedical Chromatography, 2004, v. 18, n. 1, p. 16, doi. 10.1002/bmc.286
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- Publication type:
- Article
Simple high-performance liquid chromatographic assay for melphalan in perfusate, rat liver and tumour tissue.
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- Biomedical Chromatography, 2003, v. 17, n. 7, p. 458, doi. 10.1002/bmc.273
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- Publication type:
- Article
Sensitive liquid chromatography/tandem mass spectrometry assay for absolute quantification of ITIH<sub>4</sub>-derived putative biomarker peptides in clinical serum samples.
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- Rapid Communications in Mass Spectrometry: RCM, 2010, v. 24, n. 13, p. 1842, doi. 10.1002/rcm.4588
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- Publication type:
- Article
Liquid chromatography/tandem mass spectrometric method for the quantification of eight proteolytic fragments of ITIH<sub>4</sub> with biomarker potential in human plasma and serum.
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- Rapid Communications in Mass Spectrometry: RCM, 2008, v. 22, n. 18, p. 2915, doi. 10.1002/rcm.3695
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- Publication type:
- Article
Development and validation of an HPLC–MS/MS method to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue‐related matrices.
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- Biomedical Chromatography, 2023, v. 37, n. 11, p. 1, doi. 10.1002/bmc.5720
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- Publication type:
- Article
Bioanalytical assay for the quantification of the tyrosine kinase inhibitor EAI045 and its major metabolite PIA in mouse plasma and tissue homogenates using liquid chromatography–tandem mass spectrometry.
- Published in:
- Biomedical Chromatography, 2022, v. 36, n. 11, p. 1, doi. 10.1002/bmc.5457
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- Publication type:
- Article
A robust, accurate, sensitive LC–MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells.
- Published in:
- Biomedical Chromatography, 2022, v. 36, n. 5, p. 1, doi. 10.1002/bmc.5307
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- Publication type:
- Article
Quantification of cystine in human renal proximal tubule cells using liquid chromatography–tandem mass spectrometry.
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- Biomedical Chromatography, 2018, v. 32, n. 8, p. 1, doi. 10.1002/bmc.4238
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- Publication type:
- Article
Liquid chromatography-tandem mass spectrometric assay for the multikinase inhibitor regorafenib in plasma.
- Published in:
- Biomedical Chromatography, 2014, v. 28, n. 10, p. 1366, doi. 10.1002/bmc.3176
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- Publication type:
- Article
Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma.
- Published in:
- Biomedical Chromatography, 2007, v. 21, n. 6, p. 621, doi. 10.1002/bmc.797
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- Publication type:
- Article
Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma.
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- Biomedical Chromatography, 2006, v. 20, n. 8, p. 671, doi. 10.1002/bmc.667
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- Publication type:
- Article
Liquid chromatographic assay for the protease inhibitor atazanavir in plasma.
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- Biomedical Chromatography, 2006, v. 20, n. 1, p. 72, doi. 10.1002/bmc.530
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- Publication type:
- Article
A pharmacokinetic and pharmacodynamic model for intravenous bisphosphonate (pamidronate) in osteoporosis.
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- European Journal of Clinical Pharmacology, 2002, v. 57, n. 12, p. 883, doi. 10.1007/s00228-001-0411-8
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- Publication type:
- Article
Population Pharmacokinetics of Caffeine and its Metabolites Theobromine, Paraxanthine and Theophylline after Inhalation in Combination with Diacetylmorphine.
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- Basic & Clinical Pharmacology & Toxicology, 2005, v. 96, n. 1, p. 71, doi. 10.1111/j.1742-7843.2005.pto960111.x
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- Publication type:
- Article
OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of the NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.
- Published in:
- 2020
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- Publication type:
- journal article
Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools.
- Published in:
- 2004
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- Publication type:
- journal article
Population pharmacokinetics and pharmacodynamics of mitomycin during intraoperative hyperthermic intraperitoneal chemotherapy.
- Published in:
- 2004
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- Publication type:
- journal article
P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib.
- Published in:
- International Journal of Cancer, 2018, v. 143, n. 8, p. 2029, doi. 10.1002/ijc.31582
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- Publication type:
- Article
Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
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- International Journal of Cancer, 2014, v. 134, n. 6, p. 1484, doi. 10.1002/ijc.28475
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- Publication type:
- Article
Cerebrospinal Fluid Concentration of the RET Inhibitor Pralsetinib: A Case Report.
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- Case Reports in Oncology, 2023, v. 16, n. 1, p. 1579, doi. 10.1159/000535172
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- Publication type:
- Article
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
- Published in:
- Pigment Cell & Melanoma Research, 2015, v. 28, n. 3, p. 307, doi. 10.1111/pcmr.12364
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- Publication type:
- Article
The absolute quantification of eight inter-α-trypsin inhibitor heavy chain 4 (ITIH.
- Published in:
- Proteomics - Clinical Applications, 2010, v. 4, n. 12, p. 931, doi. 10.1002/prca.201000035
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- Publication type:
- Article
Use of chloroquine in reducing mother to child transmission of HIV-1 during breastfeeding.
- Published in:
- 2009
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- Publication type:
- Abstract