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Systematic development of ionizable lipid nanoparticles for placental mRNA delivery using a design of experiments approach.
Published in:
Bioactive Materials, 2024, v. 34, p. 125, doi. 10.1016/j.bioactmat.2023.11.014
By:
- Young, Rachel E.;
- Nelson, Katherine M.;
- Hofbauer, Samuel I.;
- Vijayakumar, Tara;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Papachristou, Charalampos;
- Gleghorn, Jason P.;
- Riley, Rachel S.
Publication type:
Article
Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37795-0
By:
- Prompetchara, Eakachai;
- Ketloy, Chutitorn;
- Alameh, Mohamad-Gabriel;
- Tharakhet, Kittipan;
- Kaewpang, Papatsara;
- Yostrerat, Nongnaphat;
- Pitakpolrat, Patrawadee;
- Buranapraditkun, Supranee;
- Manopwisedjaroen, Suwimon;
- Thitithanyanont, Arunee;
- Jongkaewwattana, Anan;
- Hunsawong, Taweewan;
- Im-Erbsin, Rawiwan;
- Reed, Matthew;
- Wijagkanalan, Wassana;
- Patarakul, Kanitha;
- Techawiwattanaboon, Teerasit;
- Palaga, Tanapat;
- Lam, Kieu;
- Heyes, James
Publication type:
Article
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-022-35637-z
By:
- Han, Xuexiang;
- Gong, Ningqiang;
- Xue, Lulu;
- Billingsley, Margaret M.;
- El-Mayta, Rakan;
- Shepherd, Sarah J.;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14504, doi. 10.3390/ijms232314504
By:
- Liu, Wei;
- Alameh, Mohamad-Gabriel;
- Yang, June F.;
- Xu, Jonathan R.;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Weissman, Drew;
- You, Jianxin
Publication type:
Article
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02441-2
By:
- Carrasco, Manuel J.;
- Alishetty, Suman;
- Alameh, Mohamad-Gabriel;
- Said, Hooda;
- Wright, Lacey;
- Paige, Mikell;
- Soliman, Ousamah;
- Weissman, Drew;
- Cleveland IV, Thomas E.;
- Grishaev, Alexander;
- Buschmann, Michael D.
Publication type:
Article
Innate and Adaptive Immune Parameters following mRNA Vaccination in Mice.
Published in:
Vaccines, 2024, v. 12, n. 5, p. 543, doi. 10.3390/vaccines12050543
By:
- Bonam, Srinivasa Reddy;
- Hazell, Nicholas C.;
- Mathew, Mano Joseph;
- Liang, Yuejin;
- Zhang, Xuxiang;
- Wei, Zhi;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Hu, Haitao
Publication type:
Article
Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and Opportunities.
Published in:
Vaccines, 2021, v. 9, n. 12, p. 1490, doi. 10.3390/vaccines9121490
By:
- Ghattas, Majed;
- Dwivedi, Garima;
- Lavertu, Marc;
- Alameh, Mohamad-Gabriel
Publication type:
Article
Nanomaterial Delivery Systems for mRNA Vaccines.
Published in:
Vaccines, 2021, v. 9, n. 1, p. 65, doi. 10.3390/vaccines9010065
By:
- Buschmann, Michael D.;
- Carrasco, Manuel J.;
- Alishetty, Suman;
- Paige, Mikell;
- Alameh, Mohamad Gabriel;
- Weissman, Drew
Publication type:
Article
mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 01, doi. 10.3389/fimmu.2022.983000
By:
- Chutamath Sittplangkoon;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Eakachai Prompetchara;
- Palaga, Tanapat
Publication type:
Article
An ionizable lipid toolbox for RNA delivery.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27493-0
By:
- Han, Xuexiang;
- Zhang, Hanwen;
- Butowska, Kamila;
- Swingle, Kelsey L.;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45422-9
By:
- Lulu Xue;
- Hamilton, Alex G.;
- Gan Zhao;
- Xiao, Zebin;
- El-Mayta, Rakan;
- Xuexiang Han;
- Ningqiang Gong;
- Xinhong Xiong;
- Junchao Xu;
- Figueroa-Espada, Christian G.;
- Shepherd, Sarah J.;
- Mukalel, Alvin J.;
- Alameh, Mohamad-Gabriel;
- Jiaxi Cui;
- Wang, Karin;
- Vaughan, Andrew E.;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45537-z
By:
- Han, Xuexiang;
- Xu, Junchao;
- Xu, Ying;
- Alameh, Mohamad-Gabriel;
- Xue, Lulu;
- Gong, Ningqiang;
- El-Mayta, Rakan;
- Palanki, Rohan;
- Warzecha, Claude C.;
- Zhao, Gan;
- Vaughan, Andrew E.;
- Wilson, James M.;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45537-z
By:
- Han, Xuexiang;
- Xu, Junchao;
- Xu, Ying;
- Alameh, Mohamad-Gabriel;
- Xue, Lulu;
- Gong, Ningqiang;
- El-Mayta, Rakan;
- Palanki, Rohan;
- Warzecha, Claude C.;
- Zhao, Gan;
- Vaughan, Andrew E.;
- Wilson, James M.;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39246-2
By:
- Brooks, Dominique L.;
- Carrasco, Manuel J.;
- Qu, Ping;
- Peranteau, William H.;
- Ahrens-Nicklas, Rebecca C.;
- Musunuru, Kiran;
- Alameh, Mohamad-Gabriel;
- Wang, Xiao
Publication type:
Article
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta.
Published in:
Small, 2024, v. 20, n. 41, p. 1, doi. 10.1002/smll.202303568
By:
- Safford, Hannah C.;
- Swingle, Kelsey L.;
- Geisler, Hannah C.;
- Hamilton, Alex G.;
- Thatte, Ajay S.;
- Ghalsasi, Aditi A.;
- Billingsley, Margaret M.;
- Alameh, Mohamad‐Gabriel;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.
Published in:
Small, 2024, v. 20, n. 11, p. 1, doi. 10.1002/smll.202304378
By:
- Billingsley, Margaret M.;
- Gong, Ningqiang;
- Mukalel, Alvin J.;
- Thatte, Ajay S.;
- El‐Mayta, Rakan;
- Patel, Savan K.;
- Metzloff, Ann E.;
- Swingle, Kelsey L.;
- Han, Xuexiang;
- Xue, Lulu;
- Hamilton, Alex G.;
- Safford, Hannah C.;
- Alameh, Mohamad‐Gabriel;
- Papp, Tyler E.;
- Parhiz, Hamideh;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
Cover Image.
Published in:
Journal of Biomedical Materials Research, Part A, 2022, v. 110, n. 5, p. 1, doi. 10.1002/jbm.a.37385
By:
- Zhang, Hanwen;
- Han, Xuexiang;
- Alameh, Mohamad‐Gabriel;
- Shepherd, Sarah J.;
- Padilla, Marshall S.;
- Xue, Lulu;
- Butowska, Kamila;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
Rational design of anti‐inflammatory lipid nanoparticles for mRNA delivery.
Published in:
Journal of Biomedical Materials Research, Part A, 2022, v. 110, n. 5, p. 1101, doi. 10.1002/jbm.a.37356
By:
- Zhang, Hanwen;
- Han, Xuexiang;
- Alameh, Mohamad‐Gabriel;
- Shepherd, Sarah J.;
- Padilla, Marshall S.;
- Xue, Lulu;
- Butowska, Kamila;
- Weissman, Drew;
- Mitchell, Michael J.
Publication type:
Article
Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants.
Published in:
NPJ Vaccines, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41541-024-00957-2
By:
- Hajnik, Renee L.;
- Plante, Jessica A.;
- Reddy Bonam, Srinivasa;
- Rafael, Grace H.;
- Liang, Yuejin;
- Hazell, Nicholas C.;
- Walker, Jordyn;
- Reyna, Rachel A.;
- Walker, David H.;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Weaver, Scott C.;
- Plante, Kenneth S.;
- Hu, Haitao
Publication type:
Article
Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model.
Published in:
NPJ Vaccines, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41541-024-00901-4
By:
- England, Ross N.;
- Drapeau, Elizabeth M.;
- Alameh, Mohamad-Gabriel;
- Hosseinzadeh, Reihaneh;
- Weissman, Drew;
- Hensley, Scott E.
Publication type:
Article
Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum.
Published in:
2023
By:
- Hayashi, Clifford T. H.;
- Cao, Yi;
- Clark, Leor C.;
- Tripathi, Abhai K.;
- Zavala, Fidel;
- Dwivedi, Garima;
- Knox, James;
- Alameh, Mohamad-Gabriel;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Weissman, Drew;
- Kumar, Nirbhay
Publication type:
Correction Notice
Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum.
Published in:
2023
By:
- Hayashi, Clifford T. H.;
- Cao, Yi;
- Clark, Leor C.;
- Tripathi, Abhai K.;
- Zavala, Fidel;
- Dwivedi, Garima;
- Knox, James;
- Alameh, Mohamad-Gabriel;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Weissman, Drew;
- Kumar, Nirbhay
Publication type:
Correction Notice
A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria.
Published in:
NPJ Vaccines, 2023, v. 8, n. 1, p. 1, doi. 10.1038/s41541-023-00679-x
By:
- Chuang, Yu-Min;
- Alameh, Mohamad-Gabriel;
- Abouneameh, Selma;
- Raduwan, Hamidah;
- Ledizet, Michel;
- Weissman, Drew;
- Fikrig, Erol
Publication type:
Article
mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum.
Published in:
NPJ Vaccines, 2022, v. 7, n. 1, p. 1, doi. 10.1038/s41541-022-00577-8
By:
- Hayashi, Clifford T. H.;
- Yi Cao;
- Clark, Leor C.;
- Tripathi, Abhai K.;
- Zavala, Fidel;
- Dwivedi, Garima;
- Knox, James;
- Alameh, Mohamad-Gabriel;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Weissman, Drew;
- Kumar, Nirbhay
Publication type:
Article
A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1.
Published in:
Viruses (1999-4915), 2023, v. 15, n. 7, p. 1483, doi. 10.3390/v15071483
By:
- Egan, Kevin P.;
- Awasthi, Sita;
- Tebaldi, Giulia;
- Hook, Lauren M.;
- Naughton, Alexis M.;
- Fowler, Bernard T.;
- Beattie, Mitchell;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Cohen, Gary H.;
- Friedman, Harvey M.
Publication type:
Article
Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine.
Published in:
Viruses (1999-4915), 2022, v. 14, n. 3, p. 540, doi. 10.3390/v14030540
By:
- Hook, Lauren M.;
- Awasthi, Sita;
- Cairns, Tina M.;
- Alameh, Mohamad-Gabriel;
- Fowler, Bernard T.;
- Egan, Kevin P.;
- Sung, Molly M. H.;
- Weissman, Drew;
- Cohen, Gary H.;
- Friedman, Harvey M.
Publication type:
Article
Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices.
Published in:
Polymers (20734360), 2024, v. 16, n. 17, p. 2547, doi. 10.3390/polym16172547
By:
- Alameh, Mohamad-Gabriel;
- Tavakoli Naeini, Ashkan;
- Dwivedi, Garima;
- Lesage, Frederic;
- Buschmann, Michael D.;
- Lavertu, Marc
Publication type:
Article
Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering.
Published in:
Advanced Healthcare Materials, 2023, v. 12, n. 30, p. 1, doi. 10.1002/adhm.202301515
By:
- Hamilton, Alex G.;
- Swingle, Kelsey L.;
- Joseph, Ryann A.;
- Mai, David;
- Gong, Ningqiang;
- Billingsley, Margaret M.;
- Alameh, Mohamad‐Gabriel;
- Weissman, Drew;
- Sheppard, Neil C.;
- June, Carl H.;
- Mitchell, Michael J.
Publication type:
Article
Editorial: RNA vaccines for prevalent and newly emerging diseases.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1474260
By:
- López-Camacho, César;
- Alameh, Mohamad Gabriel;
- Peer, Dan;
- Culis, Pieter
Publication type:
Article
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1426232
By:
- Guenaga, Javier;
- Alirezaei, Mehrdad;
- Yu Feng;
- Alameh, Mohamad-Gabriel;
- Wen-Hsin Lee;
- Baboo, Sabyasachi;
- Cluff, Jocelyn;
- Wilson, Richard;
- Bale, Shridhar;
- Ozorowski, Gabriel;
- Lin, Paulo;
- Ying Tam;
- Diedrich, Jolene K.;
- Yates III, John R.;
- Paulson, James C.;
- Ward, Andrew B.;
- Weissman, Drew;
- Wyatt, Richard T.
Publication type:
Article
Immunization with PfGBP130 generates antibodies that inhibit RBC invasion by P. falciparum parasites.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1350560
By:
- Johnson, Yannick;
- Shakri, Ahmad Rushdi;
- Pond-Tor, Sunthorn;
- Jnawali, Anup;
- Najrana, Tanbir;
- Haiwei Wu;
- Badhai, Jhasketan;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Kabyemela, Edward;
- Duffy, Patrick;
- Fried, Michal;
- Kurtis, Jonathan;
- Raj, Dipak Kumar
Publication type:
Article
Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48555-z
By:
- Furey, Colleen;
- Scher, Gabrielle;
- Naiqing Ye, Naiqing;
- Kercher, Lisa;
- DeBeauchamp, Jennifer;
- Crumpton, Jeri Carol;
- Jeevan, Trushar;
- Patton, Christopher;
- Franks, John;
- Rubrum, Adam;
- Alameh, Mohamad-Gabriel;
- Fan, Steven H. Y.;
- Phan, Anthony T.;
- Hunter, Christopher A.;
- Webby, Richard J.;
- Weissman, Drew;
- Hensley, Scott E.
Publication type:
Article
TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue.
Published in:
Science Translational Medicine, 2024, v. 16, n. 732, p. 1, doi. 10.1126/scitranslmed.adg6229
By:
- Zhao, Gan;
- Xue, Lulu;
- Weiner, Aaron I.;
- Gong, Ningqiang;
- Adams-Tzivelekidis, Stephanie;
- Wong, Joanna;
- Gentile, Maria E.;
- Nottingham, Ana N.;
- Basil, Maria C.;
- Lin, Susan M.;
- Niethamer, Terren K.;
- Diamond, Joshua M.;
- Bermudez, Christian A.;
- Cantu, Edward;
- Han, Xuexiang;
- Cao, Yaqi;
- Alameh, Mohamad-Gabriel;
- Weissman, Drew;
- Morrisey, Edward E.;
- Mitchell, Michael J.
Publication type:
Article
Dual spike and nucleocapsid mRNA vaccination confer protection against SARS-CoV-2 Omicron and Delta variants in preclinical models.
Published in:
Science Translational Medicine, 2022, v. 14, n. 662, p. 1, doi. 10.1126/scitranslmed.abq1945
By:
- Hajnik, Renee L.;
- Plante, Jessica A.;
- Liang, Yuejin;
- Alameh, Mohamad-Gabriel;
- Tang, Jinyi;
- Bonam, Srinivasa Reddy;
- Zhong, Chaojie;
- Adam, Awadalkareem;
- Scharton, Dionna;
- Rafael, Grace H.;
- Liu, Yang;
- Hazell, Nicholas C.;
- Sun, Jiaren;
- Soong, Lynn;
- Shi, Pei-Yong;
- Wang, Tian;
- Walker, David H.;
- Sun, Jie;
- Weissman, Drew;
- Weaver, Scott C.
Publication type:
Article
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy (Adv. Mater. 26/2024).
Published in:
Advanced Materials, 2024, v. 36, n. 26, p. 1, doi. 10.1002/adma.202470201
By:
- Metzloff, Ann E.;
- Padilla, Marshall S.;
- Gong, Ningqiang;
- Billingsley, Margaret M.;
- Han, Xuexiang;
- Merolle, Maria;
- Mai, David;
- Figueroa‐Espada, Christian G.;
- Thatte, Ajay S.;
- Haley, Rebecca M.;
- Mukalel, Alvin J.;
- Hamilton, Alex G.;
- Alameh, Mohamad‐Gabriel;
- Weissman, Drew;
- Sheppard, Neil C.;
- June, Carl H.;
- Mitchell, Michael J.
Publication type:
Article
Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy.
Published in:
Advanced Materials, 2024, v. 36, n. 26, p. 1, doi. 10.1002/adma.202313226
By:
- Metzloff, Ann E.;
- Padilla, Marshall S.;
- Gong, Ningqiang;
- Billingsley, Margaret M.;
- Han, Xuexiang;
- Merolle, Maria;
- Mai, David;
- Figueroa‐Espada, Christian G.;
- Thatte, Ajay S.;
- Haley, Rebecca M.;
- Mukalel, Alvin J.;
- Hamilton, Alex G.;
- Alameh, Mohamad‐Gabriel;
- Weissman, Drew;
- Sheppard, Neil C.;
- June, Carl H.;
- Mitchell, Michael J.
Publication type:
Article
Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-04555-1
By:
- Connors, Jennifer;
- Joyner, David;
- Mege, Nathan J.;
- Cusimano, Gina M.;
- Bell, Matthew R.;
- Marcy, Jennifer;
- Taramangalam, Bhavani;
- Kim, Kenneth M.;
- Lin, Paulo J. C.;
- Tam, Ying K.;
- Weissman, Drew;
- Kutzler, Michele A.;
- Alameh, Mohamad-Gabriel;
- Haddad, Elias K.
Publication type:
Article

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