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- Title
Loss of Intra-Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV-Infected Women.
- Authors
Strbo, Natasa; Alcaide, Maria L.; Romero, Laura; Bolivar, Hector; Jones, Deborah; Podack, Eckhard R.; Fischl, Margaret A.
- Abstract
Problem Human gamma delta ( GD) T cells play a well-documented role in epithelial barrier surveillance and protection. Two subsets of GD T cells, defined by the use of either the Vdelta2 ( GD2) or Vdelta1 ( GD1) TCR, predominate. We hypothesized that endocervical GD T cells play important role in lower genital tract anti- HIV immune responses. Method of study HIV-infected ( n = 18) and HIV-uninfected ( n = 19) pre-menopausal women participating in the WIHS cohort were recruited. Frequency and phenotype of GD T cells were determined in endocervical cytobrush samples and peripheral blood by multicolor flow cytometry. Results We found depletion of GD2 cells in the blood of HIV-infected women as well as significant decrease in the frequency of endocervical GD1 cells compared to uninfected women. Conclusion We report for the first time, the GD1 cells are a predominant endocervical T-cell subset that is significantly decreased in HIV-infected women.
- Subjects
HIV-positive women; EPITHELIAL cells; IMMUNE response; BLOOD testing; T cells; CELL physiology
- Publication
American Journal of Reproductive Immunology, 2016, Vol 75, Issue 2, p134
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12458