We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS‐induced colitis.
- Authors
Cannon, Abigail R.; Kuprys, Paulius V.; Cobb, Adrienne N.; Ding, Xianzhong; Kothari, Anai N.; Kuo, Paul C.; Eberhardt, Joshua M.; Hammer, Adam M.; Morris, Niya L.; Li, Xiaoling; Choudhry, Mashkoor A.
- Abstract
Abstract: Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is “Don't Drink Alcohol” as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD. Alcohol alone not only induces a systemic pro‐inflammatory response, but can also be directly harmful to gut barrier integrity. However, how alcohol could result in the exacerbation of UC in both patients and murine models of colitis has yet to be elucidated. Therefore, we conducted a retrospective analysis of patients admitted for IBD with a documented history of alcohol use in conjunction with a newly developed mouse model of binge alcohol consumption following dextran sulfate sodium (DSS)‐induced colitis. We found that alcohol negatively impacts clinical outcomes of patients with IBD, specifically increased intestinal infections, antibiotic injections, abdomen CT scans, and large intestine biopsies. Furthermore, in our mouse model of binge alcohol consumption following an induced colitis flare, we found alcohol exacerbates weight loss, clinical scores, colonic shortening and inflammation, and propensity to infection. These findings highlight alcohol's ability to potentiate symptoms and susceptibility to infection in UC and suggest alcohol as an underlying factor in perpetuating symptoms of IBD.
- Subjects
ALCOHOL drinking &; health; INFLAMMATORY bowel disease diagnosis; ULCERATIVE colitis diagnosis; DISEASE exacerbation; INFECTION; DISEASE susceptibility; INFLAMMATION; WEIGHT loss
- Publication
Journal of Leukocyte Biology, 2018, Vol 104, Issue 3, p543
- ISSN
0741-5400
- Publication type
Article
- DOI
10.1002/JLB.4MA1217-506R