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- Title
Two-Dimensional Matrix Algorithm Using Detrended Fluctuation Analysis to Distinguish Burkitt and Diffuse Large B-Cell Lymphoma.
- Authors
Yeh, Rong-Guan; Abbod, Maysam F.; Shieh, Jiann-Shing
- Abstract
A detrended fluctuation analysis (DFA) method is applied to image analysis. The 2-dimensional (2D) DFA algorithms is proposed for recharacterizing images of lymph sections. Due to Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), there is a significant different 5-year survival rates after multiagent chemotherapy. Therefore, distinguishing the difference between BL and DLBCL is very important. In this study, eighteen BL images were classified as group A, which have one to five cytogenetic changes. Ten BL images were classified as group B, which have more than five cytogenetic changes. Both groups A and B BLs are aggressive lymphomas, which grow very fast and require more intensive chemotherapy. Finally, ten DLBCL images were classified as group C. The short-term correlation exponent a1 values of DFA of groups A, B, and C were 0.370 ± 0.033, 0.382 ± 0.022, and 0.435 ± 0.053, respectively. It was found that a1 value of BL image was significantly lower (P < 0.05) than DLBCL. However, there is no difference between the groups A and B BLs. Hence, it can be concluded that a1 value based on DFA statistics concept can clearly distinguish BL and DLBCL image.
- Subjects
B cell lymphoma; BURKITT'S lymphoma; ALGORITHMS; STOCHASTIC processes; CANCER chemotherapy; CYTOGENETICS
- Publication
Computational & Mathematical Methods in Medicine, 2012, p1
- ISSN
1748-670X
- Publication type
Article
- DOI
10.1155/2012/947191