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- Title
Autoantibody Production in Rabbits III. THE EFFECT OF INFECTION WITH <em>EIMERIA STIEDERIA</em> AND ITS RELATION TO NATURAL ANTIBODY.
- Authors
Asherson, G.L.; Rose, M. Elaine
- Abstract
The finding that the serum of apparently healthy rabbits fixed complement with rabbit liver and kidney. Has been confirmed. Experimental infection of rabbits with Eimeria stiedae, the cause of hepatic coccidiosis, led to a rise in the titre of serum complement-fixing factors. The rise was statistically significant 14,21 and 28 days after infection. The factors were regarded as antibodies because they behaved ass macroglobulins and diethylaminoethyl-cellulose chromatography and sucrose gradient centrifugation, and as auto antibodies because they fixed complement with the kidney of the rabbits in which they occurred. The antibody reacted with widely distributed antigen(s) with activity in brain and low activity in skeletal muscle. The possibility that coccidial infection may be responsible for the natural autoantibody of rabbits is discussed.
- Subjects
AUTOANTIBODIES; IMMUNOGLOBULINS; RABBITS; EIMERIA; GLOBULINS; BLOOD proteins
- Publication
Immunology, 1963, Vol 6, Issue 3, p207
- ISSN
0019-2805
- Publication type
Article