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- Title
RNA-seq Permits a Closer Look at Normal Skin and Psoriasis Gene Networks.
- Authors
Quigley, David
- Abstract
Psoriasis is a chronic inflammatory skin disease driven by aberrant signals from the immune system. In this issue, Li et al. present the first large RNA-seq analysis of gene expression in normal skin and psoriasis lesions, providing a more comprehensive view of mRNA expression than earlier microarray studies. This study's size enables gene co-expression analysis, a method illustrating which pathways are altered by the presence of disease.
- Subjects
NUCLEOTIDE sequence; PSORIASIS &; genetics; IMMUNE system; MESSENGER RNA; GENE expression
- Publication
Journal of Investigative Dermatology, 2014, Vol 134, Issue 7, p1789
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.2014.66