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- Title
Retinoic acids up-regulate functional eosinophil-driving receptor CCR3.
- Authors
Ueki, S.; Nishikawa, J.; Yamauchi, Y.; Konno, Y.; Tamaki, M.; Itoga, M.; Kobayashi, Y.; Takeda, M.; Moritoki, Y.; Ito, W.; Chihara, J.
- Abstract
Eotaxins and their receptor CCR3 have a definitive role for tissue accumulation of eosinophils both under homeostatic and pathologic conditions. However, physiological stimuli that can up-regulate CCR3 in blood-derived human eosinophils have not been recognized. As a prior gene microarray study revealed up-regulation of CCR3 in eosinophils stimulated with retinoic acids ( RAs), the expression of functional CCR3 was examined. We found that 9-cis RA and all-trans RA ( ATRA) significantly induced surface CCR3 expression regardless of the presence of IL-3 or IL-5. Pharmacological manipulations with receptor-specific agonists and antagonists indicated that retinoic acid receptor-α activation is critical for CCR3 up-regulation. RA-induced CCR3 was associated with its functional capacity, in terms of the calcium mobilization and chemotactic response to eotaxin-1 ( CCL11). Our study suggests an important role of vitamin A derivatives in the tissue accumulation of eosinophils.
- Subjects
RETINOIC acid receptors; EOSINOPHILS; EOTAXIN; HOMEOSTASIS; GENE expression; PHARMACOLOGY
- Publication
Allergy, 2013, Vol 68, Issue 7, p953
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12175