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- Title
Effect of β<sub>2</sub>-agonist, clenbuterol on the number of white blood cells in rats.
- Authors
Shirato, Ken; Tanihata, Jun; Motohashi, Norio; Taehiyashiki, Kaoru; Tomoda, Akio; Imaizumi, Kazuhiko
- Abstract
Clenbuterol (CLE: 4-amino-α(t-butyl-amino)methyl-3,5-diehlorobenzyl alcohol) is well known as the potent β2-adrenergic agonist and nonsteroidal anabolic drug, thus generally used for the sports doping and asthma therapy. However, the administration effects of CLE on immune-responsive systems have not been elucidated. Therefore, the administration effects of CLE on the number of white blood cells were studied in rats. Male adult rats were divided into the control and CLE-administered groups to compare the number of total white blood cells, neutrophil, monocyte, lymphocytes, eosinophil, and basophil. The administration (dose = 1.0 mg · kg-1 body weight · day-1) of CLE was maintained for 30 days. The administration of CLE did not change the number of total white blood cells during the experimental period. However, the administration of CLE decreased drastically the number of lymphoeytes and eosinophil, while increased significantly the number of monocyte and neutrophil during the experimental period. There was no significant change in the number of basophil during the experimental period. These results suggest that the administration of CLE induces drastic redistribution of circulating white blood cells without changing the number of total white blood cells, and these redistribution responses of circulating white blood cells during the administration of CLE are sustained for at least 30 days.
- Subjects
CLENBUTEROL; LEUCOCYTES; NEUTROPHILS; MONOCYTES; LYMPHOCYTES; EOSINOPHILS; BASOPHILS; LABORATORY rats
- Publication
FASEB Journal, 2007, Vol 21, Issue 6, pA1392
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fasebj.21.6.a936-a