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- Title
Prognostic value of the distance between the primary tumor and brainstem in the patients with locally advanced nasopharyngeal carcinoma.
- Authors
Yuxiang He; Ying Wang; Lin Shen; Yajie Zhao; Pengfei Cao; Mingjun Lei; Dengming Chen; Tubao Yang; Liangfang Shen; Shousong Cao; He, Yuxiang; Wang, Ying; Shen, Lin; Zhao, Yajie; Cao, Pengfei; Lei, Mingjun; Chen, Dengming; Yang, Tubao; Shen, Liangfang; Cao, Shousong
- Abstract
<bold>Background: </bold>Brainstem dose limitations influence radiation dose reaching to tumor in the patients with locally-advanced nasopharyngeal cancer (NPC).<bold>Methods: </bold>A retrospective analysis of the prognostic value of the distance between the primary tumor and brainstem (Dbs) in 358 patients with locally-advanced NPC after intensity-modulated radiation therapy (IMRT). Receiver operating characteristic (ROC) curves were used to identify the cut-off value to analyze the impact of Dbs on tumor dose coverage and prognosis.<bold>Results: </bold>The three-year overall survival (OS), local relapse-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) were 88.8 vs. 78.4% (P = 0.007), 96.5 vs. 91.1% (P = 0.018), 87.8 vs. 79.3% (P = 0.067), and 84.1 vs. 69.6% (P = 0.002) for the patients with the Dbs > 4.7 vs. ≤ 4.7 mm, respectively. ROC curves revealed Dbs (4.7 mm) combined with American Joint Committee on Cancer (AJCC) T classification had a significantly better prognostic value for OS (P < 0.05).<bold>Conclusions: </bold>Dbs (≤ 4.7 mm) is an independent negative prognostic factor for OS/LRFS/DFS and enhances the prognostic value of T classification in the patients with locally-advanced NPC.
- Subjects
NASOPHARYNX cancer; BRAIN stem; INTENSITY modulated radiotherapy; CANCER relapse; RETROSPECTIVE studies; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; NASOPHARYNX tumors; PROGNOSIS; RADIOTHERAPY; RESEARCH; EVALUATION research; RELATIVE medical risk; PREDICTIVE tests; RECEIVER operating characteristic curves; DIAGNOSIS
- Publication
BMC Cancer, 2016, Vol 16, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-016-2148-x