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- Title
Ultrasound-promoted synthesis of 4(3H)-quinazolines under Yb(OTf)<sub>3</sub> catalysis.
- Authors
Fiorito, Serena; Taddeo, Vito A.; Epifano, Francesco; Genovese, Salvatore
- Abstract
A novel method to perform the Niementowski reaction leading to 4(3H)-quinazolines is reported. The 4(3H)- quinazolines were obtained in good to excellent yields by microwave irradiation or ultrasound-assisted synthesis from 2-aminobenzonitrile and acyl chlorides in solvent-free conditions and in the presence of Yb(OTf)3 (10 mol%). Ultrasound-based methodology performed better than the microwave-assisted process in terms of yields for all examples. The procedure reported herein represents also the first reported example of an ultrasound-promoted Niementowski-like reaction.
- Subjects
QUINAZOLINE; HETEROCYCLIC compounds synthesis; YTTERBIUM compounds; NIEMENTOWSKI reaction; ULTRASONIC imaging; IRRADIATION; CATALYSIS
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2017, Vol 2017, p68
- ISSN
1551-7004
- Publication type
Article
- DOI
10.3998/ark.5550190.p009.710