We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ibuprofen Loaded Electrospun Polymeric Nanofibers: A Strategy to Improve Oral Absorption.
- Authors
Panda, Dibya Sundar; Alruwaili, Nabil K.; Swain, Kalpana; Pattnaik, Satyanarayan
- Abstract
The poor aqueous solubility of candidate drugs has presented a great challenge to formulation scientists for their effective oral delivery. Poor solubility is often associated with poor dissolution behavior and, subsequently, poor bioavailability for those drugs when intestinal absorption is dissolution rate limited. In the present study electrospun polymeric nanofibers were developed to address the poor aqueous solubility of ibuprofen, a Biopharmaceutic Classification System (BCS) class-II drug. Hydrophilic spinnable polymers like polyvinyl pyrrolidone were deployed as a carrier system for the fabrication of nanofibers. The electrospinning parameters like flow rate, voltage, and spinneret to collector distance were optimized. The fabricated ibuprofen-loaded nanofibers were characterized using scanning electron microscopy and differential scanning calorimetry. Drug release studies and ex vivo intestinal absorption studies were also carried out. The nanofiber-based platform significantly improved in vitro absorption of ibuprofen compared to pure ibuprofen crystals.
- Subjects
NANOFIBERS; IBUPROFEN; DRUG solubility; DIFFERENTIAL scanning calorimetry; INTESTINAL absorption; SCANNING electron microscopy
- Publication
Acta Chimica Slovenica, 2022, Vol 69, Issue 2, p483
- ISSN
1318-0207
- Publication type
Article
- DOI
10.17344/acsi.2022.7370