We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Helicobacter pylori infection in relation to gastric cancer progression.
- Authors
Venkateshwari, A.; Krishnaveni, D.; Venugopal, S.; Shashikumar, P.; Vidyasagar, A.; Jyothy, A.
- Abstract
Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
- Subjects
STOMACH cancer risk factors; PYLORIC spasms; CARCINOGENESIS; MICROBIAL virulence; DEVELOPING countries
- Publication
Indian Journal of Cancer, 2011, Vol 48, Issue 1, p94
- ISSN
0019-509X
- Publication type
Article
- DOI
10.4103/0019-509X.75840