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- Title
Osmotic demyelination syndrome in Intensive Care Unit.
- Authors
Rao, Parnandi Bhaskar; Azim, Afzal; Singh, Neha; Baronia, Arvind Kumar; Kumar, Anand; Poddar, Banani
- Abstract
Dyselectrolytemia, especially hyponatremia is a common occurrence in hospitalized patients, and a number of dreaded complications arise out of the disorder itself and its treatment. Osmotic demyelination syndrome develops secondary to rapid correction of hyponatremia. As the disease is rare and available literature from Intensive Care Units are limited, we report our retrospective observation over 5 years. Overall incidence was 2.5% with altered sensorium and hypokalemia as most common symptom and associated factor respectively. Isolated pontine involvement was in 41% and combined pontine, and extra-pontine lesions were found in 23% of cases. All patients received supportive therapy; out of which 2 died and complete neurological recovery was seen in 24% of patients. Our findings suggest that a well organized supportive therapy and multidisciplinary approach is of more concern than many available therapeutic modalities which are still to be proved.
- Subjects
HYPONATREMIA; SYNDROMES; DEMYELINATION; INTENSIVE care units; MAGNETIC resonance imaging; TIME; TREATMENT effectiveness; DISEASE incidence; RETROSPECTIVE studies; DIAGNOSIS
- Publication
Indian Journal of Critical Care Medicine, 2015, Vol 19, Issue 3, p166
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/0972-5229.152760