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- Title
LDL's unexpected travel partners in the road to atherosclerosis.
- Authors
Ben-Aicha, Soumaya; Ibañez, Borja
- Abstract
These results suggest that LDL-msRNA instigates inflammation associated with atherosclerosis and supports alternative functions of LDL beyond cholesterol transport. Atherosclerosis is the pathophysiological base for most forms of cardiovascular disease (CVD).[2] The disease is driven by a large number of known factors, including inflammation, oxidative stress, and metabolic dysfunction, and many more to be unravelled. Keywords: Macrophage; LDL; TLR8; sRNA; CVD EN Macrophage LDL TLR8 sRNA CVD e146 e148 3 11/01/23 20230901 NES 230901 Commentary on 'LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8' by R.M. Allen I et al. i , I Nature Cell Biology i , https://doi.org/10.1038/s41556-022-01030-7.[1] Atherosclerosis is a complex disease that is characterized by the accumulation of fatty deposits in arteries. Finally, the study investigated the effects of nt-LNA on atherosclerosis in mice, validating a reduction in the development of atherosclerosis in mice fed with Western diet.
- Subjects
ATHEROSCLEROTIC plaque; LOW density lipoproteins; ATHEROSCLEROSIS; NITRIC-oxide synthases; MACROPHAGE colony-stimulating factor; NF-kappa B
- Publication
Cardiovascular Research, 2023, Vol 119, Issue 13, pe146
- ISSN
0008-6363
- Publication type
Article
- DOI
10.1093/cvr/cvad131