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- Title
TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B‐cell NHL.
- Authors
Gava, F.; Faria, C.; Gravelle, P.; Garcia‐Valero, J.; Quelen, C.; Serrat, N.; Gower, N.; Morschhauser, F.; Fournié, J.; Bouquet, F.; Fonseca, C.; Herter, S.; Codarri, L.; McCord, R.; Chiang, E.; Laurent, C.; Perez‐Galan, P.; Ysebaert, L.; Bezombes, C.
- Abstract
Relapsed/refractory B-cell NHLs are made up with a heterogeneous array of incurable diseases, whose outcomes in the rituximab era are unclear, despite patients benefit from new therapeutic strategies. Here, we present a new preclinical follicular lymphoma (FL) 3D model called Patient-Derived Lymphoma Spheroid (FL-PDLS) that recapitulates the FL pathogenesis and the B cells-immune tumor microenvironment crosstalk. This system can evolve towards full FL-TME reconstituted organoids and therefore become powerful theragnostic biomaterials that combine therapy with diagnosis necessary for individualized therapies for patients.
- Subjects
LYMPHOMAS; EMPLOYEE ownership; FOLLICULAR lymphoma; B cells; NON-Hodgkin's lymphoma
- Publication
Hematological Oncology, 2023, Vol 41, p286
- ISSN
0278-0232
- Publication type
Article
- DOI
10.1002/hon.3164_197