We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Efficacy of palonosetron to prevent delayed nausea and vomiting in non-Hodgkin's lymphoma patients undergoing repeated cycles of the CHOP regimen.
- Authors
Bungo Saito; Hidetoshi Nakashima; Maasa Abe; So Murai; Yuta Baba; Nana Arai; Yukiko Kawaguchi; Shun Fujiwara; Nobuyuki Kabasawa; Hiroyuki Tsukamoto; Yui Uto; Hirotsugu Ariizumi; Kouji Yanagisawa; Norimichi Hattori; Hiroshi Harada; Tsuyoshi Nakamaki
- Abstract
<bold>Purpose: </bold>Few studies have investigated the effect of palonosetron on delayed chemotherapy-induced nausea and vomiting in lymphoma patients receiving the CHOP regimen. We conducted a prospective clinical trial to assess the efficacy of palonosetron in patients receiving the CHOP regimen.<bold>Methods: </bold>Complete control (CC: emesis-free and mild nausea) during delayed phase (24-120 h) was the primary endpoint. The secondary endpoint was complete response (CR: emesis-free) during acute (0-24 h), delayed, and overall phases (0-120 h), and CC during acute and overall phases. Palonosetron (0.75 mg) was administered before chemotherapy on day 1 of both the first and second CHOP cycles.<bold>Results: </bold>The efficacy of palonosetron in preventing emesis was evaluated in 40 patients. Across two cycles, over 85% of patients achieved CR. As the primary endpoint, the proportion of patients achieving CC in the delayed phase increased from 70% (cycle 1) to 85% (cycle 2). CR rate in the delayed phase increased from 85% (cycle 1) to 95% (cycle 2).<bold>Conclusion: </bold>These results suggest that the antiemetic effects during the delayed phase were inferior to those in the acute phase during the first cycle. However, even at the same dose of palonosetron, CR and CC rates increased in the second cycle.
- Subjects
CANCER chemotherapy; CANCER patients; LYMPHOMA treatment; CHEMOTHERAPY complications; PHYSIOLOGICAL effects of chemotherapy; LYMPHOMA diagnosis; ANTINEOPLASTIC agents; CLINICAL trials; DOXORUBICIN; HETEROCYCLIC compounds; ISOQUINOLINE; LONGITUDINAL method; LYMPHOMAS; NAUSEA; PREDNISONE; VINCRISTINE; VOMITING; PHARMACODYNAMICS; CYCLOPHOSPHAMIDE; THERAPEUTICS
- Publication
Supportive Care in Cancer, 2018, Vol 26, Issue 1, p269
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-017-3845-y