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- Title
Relationship of promising methods in the detection of anthracycline-induced cardiotoxicity in breast cancer patients.
- Authors
Bulten, Ben; Verberne, Hein; Bellersen, Louise; Oyen, Wim; Sabaté-Llobera, Aida; Mavinkurve-Groothuis, Annelies; Kapusta, Livia; Laarhoven, Hanneke; Geus-Oei, Lioe-Fee; Bulten, Ben F; Verberne, Hein J; Oyen, Wim J G; Sabaté-Llobera, Aida; Mavinkurve-Groothuis, Annelies M C; van Laarhoven, Hanneke W M; de Geus-Oei, Lioe-Fee
- Abstract
<bold>Purpose: </bold>It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated (123)I-metaiodobenzylguanidine ((123)I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers. <bold>Methods: </bold>We performed (123)I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT (123)I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson's r and multivariate analyses were performed to identify correlations and independent predictors of (123)I-mIBG scintigraphy results. <bold>Results: </bold>Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust (123)I-mIBG parameters. Significant correlations were observed between (123)I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson's r was observed between delayed H/M ratio and GRS (Pearson's r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023). <bold>Conclusion: </bold>The delayed planar H/M ratio is the most robust (123)I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.
- Publication
Cancer Chemotherapy & Pharmacology, 2015, Vol 76, Issue 5, p957
- ISSN
0344-5704
- Publication type
journal article
- DOI
10.1007/s00280-015-2874-9