We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of Nonalcoholic Steatohepatitis between Males and Females.
- Authors
Tan, Darren; Chan, Kai En; Wong, Zhen Yu; Ng, Cheng Han; Xiao, Jieling; Lim, Wen Hui; Tay, Phoebe; Tang, Ansel; Fu, Clarissa Elysia; Muthiah, Mark; Nah, Benjamin; Tan, Eunice X.; Teng, Margaret L.P.; Siddiqui, Mohammad Shadab; Dan, Yock Young; Lim, Seng Gee; Loomba, Rohit; Huang, Daniel Q.
- Abstract
Introduction: The etiology of liver diseases has changed significantly, but its impact on the comparative burden of cirrhosis between males and females is unclear. We estimated sex differences in the burden of cirrhosis across 204 countries and territories from 2010 to 2019. Methods: We analyzed temporal trends in the burden of cirrhosis using the methodology framework of the 2019 Global Burden of Disease study. We estimated annual frequencies and age-standardized rates (ASRs) of cirrhosis incidence, death, and disability-adjusted life-years (DALYs) by sex, region, country, and etiology. Results: In 2019, the frequency of incident cases, deaths, and DALYs due to cirrhosis was 1,206,125, 969,068, and 31,781,079 in males versus 845,429, 502,944, and 14,408,336 in females, respectively. From 2010 to 2019, the frequency of cirrhosis deaths increased by 9% in males and 12% in females. Incidence ASRs remained stable in males but increased in females, while death ASRs declined in both. Death ASRs for both sexes declined in all regions, except in the Americas where they remained stable. In 2019, alcohol was the leading cause of cirrhosis deaths in males, and hepatitis C in females. Death ASRs declined for all etiologies in both sexes, except in nonalcoholic steatohepatitis (NASH). The ratio of female-to-male incidence ASRs in 2019 was lowest in alcohol(0.5), and highest in NASH(1.3), while the ratio of female-to-male death ASRs was lowest in alcohol(0.3) and highest in NASH(0.8). Conclusion: The global burden of cirrhosis is higher in males. However, incidence and death ASRs from NASH cirrhosis in females are comparable to that of males.
- Subjects
NON-alcoholic fatty liver disease; HEPATITIS C; GLOBAL burden of disease; ETIOLOGY of diseases; CIRRHOSIS of the liver; EPIDEMIOLOGY
- Publication
Digestive Diseases, 2023, Vol 41, Issue 6, p900
- ISSN
0257-2753
- Publication type
Article
- DOI
10.1159/000533946