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- Title
Limitation of Left Ventricular Hypertrophy and Dysfunction by ACE Inhibition after Anterior Q-Wave Myocardial Infarction.
- Authors
Jugdutt, Bodh I.; Humen, Dennis P.
- Abstract
To determine whether limitation of left ventricular (LV) hypertrophy with angiotensin-converting enzyme inhibition after myocardial infarction (MI) is associated with improved systolic and diastolic function, quantitative two-dimensional echocardiograms and Doppler of 40 patients, who were randomized on day 3 after a first Q-wave anterior MI to receive therapy with captopril (12.5 mg t.i.d.) or placebo for 6 weeks, were analyzed for LV volumes (Simpson’s rule) and mass (3D reconstruction), remodeling parameters and peak early (E) and late (A) transmitral flow velocities and deceleration times (DT) at 3 days, 6 weeks, 6 months and 1 year. Compared to placebo over 1 year, captopril limited (p < 0.001) the increase in diastolic volume and mass, increased LV ejection fraction and diastolic E/A ratio, and decreased DT, the frequency of E and A reversal, infarct expansion and aneurysm frequency but volume/mass ratio was unchanged. Captopril over the first 6 weeks after a first Q-wave anterior MI limited LV remodeling and hypertrophy and improved both systolic and diastolic function up to 1 year.
- Subjects
LEFT heart ventricle; ACE inhibitors; CARDIAC hypertrophy; MYOCARDIAL infarction; CARDIAC contraction; DIASTOLE (Cardiac cycle); ECHOCARDIOGRAPHY; DOPPLER effect
- Publication
Cardiology, 1998, Vol 89, Issue 4, p283
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000006801