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- Title
Clinical Outcomes of Radiotherapy for Stage 1 Glottic Carcinoma: Comparing Accelerated Hyperfractionation and Once-daily Fractionation.
- Authors
MASASHI ENDO; YUKIKO FUKUDA; KOHEI OKADA; KAZUNARI OGAWA; MICHIKO NAKAMURA; SATORU TAKAHASHI; ERI MURAKAMI; CHIAKI SHIBAYAMA; MASAHIRO KAWAHARA; KEIKO AKAHANE; RYUTARO ONAGA; TAKAFUMI NAGATOMO; TAKEHARU KANAZAWA; HIROSHI NISHINO; HARUSHI MORI; KATSUYUKI SHIRAI
- Abstract
Background/Aim: Accelerated hyperfractionation (AHF) is used in head and neck cancer to improve the local control (LC) rate, but reports of outcomes for early-stage GC are limited. The outcomes of radiotherapy (RT) for stage 1 glottic carcinoma (GC) were retrospectively analyzed, comparing AHF and once-daily fractionation (ODF) using 2.0-2.4 Gy. Patients and Methods: A total of 102 patients with stage 1 GC underwent RT alone between 2007 and 2021, with 43 in the AHF group and 59 in the ODF group. A p-value less than 0.05 was considered to indicate a significant difference. Results: The 5-year LC rate was 98% in the AHF group and 91% in the ODF group (p=0.19). During RT, significantly more patients in the AHF group required opioids due to mucositis than in the ODF group (74% vs. 25%, p<0.001), and the rate of aspiration pneumonia tended to be higher in the AHF group than in the ODF group (7% vs. 0%, p=0.072). Conclusion: There was no difference in the LC rate between AHF and ODF for stage 1 GC. Moreover, the AHF group required opioids at a higher rate and tended to have a higher risk of developing aspiration pneumonia.
- Subjects
GLOTTIS cancer; RADIOTHERAPY; TREATMENT effectiveness; PNEUMONIA; MUCOSITIS
- Publication
In Vivo, 2023, Vol 37, Issue 5, p2320
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13335