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- Title
Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson's disease.
- Authors
Miltenberger-Miltenyi, Gabriel; Ortega, Roberto A.; Domingo, Aloysius; Yadav, Rachita; Nishiyama, Ayumi; Raymond, Deborah; Katsnelson, Viktoriya; Urval, Nikita; Swan, Matthew; Shanker, Vicki; Miravite, Joan; Walker, Ruth H.; Bressman, Susan B.; Ozelius, Laurie J.; Cabassa, José C.; Saunders-Pullman, Rachel
- Abstract
There is a paucity of genetic characterization in people with Parkinson's disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.
- Subjects
DOMINICAN Republic; PARKINSON'S disease; NEW Yorkers; GENETIC variation; DARDARIN
- Publication
NPJ Parkinson's Disease, 2023, Vol 9, Issue 1, p1
- ISSN
2373-8057
- Publication type
Article
- DOI
10.1038/s41531-023-00599-6