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- Title
Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry.
- Authors
Moreno-Torres, Víctor; Tarín, Carlos; Ruiz-Irastorza, Guillermo; Castejón, Raquel; Gutiérrez-Rojas, Ángela; Royuela, Ana; Durán-del Campo, Pedro; Mellor-Pita, Susana; Tutor, Pablo; Rosado, Silvia; Sánchez, Enrique; Martínez-Urbistondo, María; de Mendoza, Carmen; Yebra, Miguel; Vargas, Juan-Antonio
- Abstract
Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997–2000, 2001–2005, 2006–2010, and 2011–2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997–2000 to 31,977 in 2011–2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p < 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p < 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p < 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p < 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality.
- Subjects
SYSTEMIC lupus erythematosus; CAUSES of death; HOSPITAL admission &; discharge; CARDIOVASCULAR diseases; PUBLIC hospitals
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 24, p5749
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10245749