We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Elevated Levels of Monocyte Chemotactic Protein-1 in the Follicular Fluid Reveals Different Populations among Women with Severe Endometriosis.
- Authors
Bouet, Pierre-Emmanuel; Chao de la Barca, Juan-Manuel; Boucret, Lisa; Descamps, Philippe; Legendre, Guillaume; Hachem, Hady El; Blanchard, Simon; Jeannin, Pascale; Reynier, Pascal; May-Panloup, Pascale
- Abstract
To determine if a modification of the cytokine profile occurs in the follicular fluid (FF) of women with endometriosis undergoing in vitro fertilization (IVF), we performed a prospective observational study from January 2018 to February 2019. In total, 87 women undergoing IVF were included: 43 for severe endometriosis-related infertility and 40 controls with other causes of infertility. The cytokine profile of the FF was determined by multiplex fluorescent-bead-based technology allowing the measurement of 59 cytokines. Monocyte Chemoattractant Protein 1 (MCP-1) was the only variable retained in the multivariate analysis. We identified two subgroups of patients in the endometriosis group: MCP-1-low group (n = 23), which had FF MCP-1 levels comparable to the control group, and MCP-1-high (n = 20), which had significantly higher FF levels. Only patients in the MCP-1-high group had a significantly altered cytokine profile in the FF, and had a significantly higher serum estradiol level (p = 0.002) and a significantly lower number of oocytes recovered (p = 0.01) compared to the MCP-1-low and the control group. Our study has shown an alteration of the oocyte microenvironment in women with endometriosis associated with high follicular fluid levels of MCP-1, allowing the identification of a subgroup of endometriosis patients with a potentially worse prognosis.
- Subjects
ENDOMETRIOSIS; MONOCYTE chemotactic factor; FERTILIZATION in vitro; INFERTILITY; FLUIDS; OLIGOSPERMIA
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 5, p1306
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9051306