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- Title
Hypertension and Mild Cognitive Impairment: State-of-the-Art Review.
- Authors
Shajahan, Sultana; Peters, Ruth; Carcel, Cheryl; Woodward, Mark; Harris, Katie; Anderson, Craig S
- Abstract
BACKGROUND Mid-life hypertension is associated with cognitive decline and dementia in later life. Reducing high blood pressure (BP) with antihypertensive agents is a well-researched strategy to prevent dementia and mild cognitive impairment (MCI). However, there is still limited direct evidence to support the approach, and particularly for the treatment of the very old and those with existing MCI. METHODS This review presents an overview of the current evidence for the relationship between MCI and hypertension, and of the potential pathophysiological mechanisms related to cognitive decline and incidence dementia in relation to aging. RESULTS Although observational data are near consistent in showing an association between mid-life hypertension and MCI and/or dementia, the evidence in relation to hypertension in younger adults and the very old (age >80 years) is much more limited. Most of the commonly available antihypertensive agents appear to provide beneficial effects in reducing the risk dementia, but there is limited evidence to support such treatment in those with existing MCI. CONCLUSIONS Further studies are needed to determine the optimal levels of BP control across different age groups, especially in adults with MCI, and which class(es) of antihypertensive agents and duration of treatment best preserve cognitive function in those at risk of, or with established, MCI.
- Subjects
MILD cognitive impairment; HYPERTENSION; ANTIHYPERTENSIVE agents; COGNITION disorders; AGE groups
- Publication
American Journal of Hypertension, 2024, Vol 37, Issue 6, p385
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpae007