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- Title
A proteomic and RNA-seq transcriptomic dataset of capsaicin-aggravated mouse chronic colitis model.
- Authors
Chen, Kexin; Shen, Silan; Chen, Yiding; Jiang, Mingshan; Hu, Kehan; Zou, Yuheng; Li, Lili; Zeng, Zhen; Ma, Chunxiang; Dang, Yuan; Zhang, Hu
- Abstract
An inappropriate diet is a risk factor for inflammatory bowel disease (IBD). It is established that the consumption of spicy food containing capsaicin is strongly associated with the recurrence and worsening of IBD symptoms. Moreover, capsaicin can induce neutrophil accumulation in the lamina propria, contributing to disease deterioration. To uncover the potential signaling pathway involved in capsaicin-induced relapse and the effects of capsaicin on neutrophil activation, we performed proteomic analyses of intestinal tissues from chronic colitis mice following capsaicin administration and transcriptomic analyses of dHL-60 cells after capsaicin stimulation. Collectively, these multiomic analyses identified proteins and genes that may be involved in disease flares, thereby providing new insights for future research. Measurement(s) protein expression profile • gene expression profile Technology Type(s) mass spectrametry • RNA sequencing Factor Type(s) time, experimental factor (capsaicin) Sample Characteristic - Organism Mus musculus • Homo sapiens
- Subjects
INFLAMMATORY bowel diseases; COLITIS; GENE expression profiling; PROTEOMICS; TRANSCRIPTOMES; RNA sequencing
- Publication
Scientific Data, 2022, Vol 9, Issue 1, p1
- ISSN
2052-4463
- Publication type
Article
- DOI
10.1038/s41597-022-01637-3