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- Title
Immune-enhancing effects of Protaetia brevitarsis seulensis larvae extracts on RAW264.7 macrophages.
- Authors
Eu-Jin Ban; Bong Sun Kim; Ra-Yeong Choi; In-Woo Kim; Minchul Seo; Jae Sam Hwang; Joon Ha Lee
- Abstract
Protaetia brevitarsis seulensis larva is well-known as an edible insect. The present study aimed to explore the immune-enhancing effect of 30% ethanol extract of Protaetia brevitarsis seulensis larvae (PBE) in RAW264.7 macrophage cells. PBE were not cytotoxic to RAW264.7 cells and nitric oxide production increased on PBE treatment in a dose-dependent manner. Furthermore, PBE significantly promoted the expression of immune-related mediators (iNOS and COX-2) and cytokines (TNF-α, IL-6, and IL-1β) and the phosphorylation of MAPKs (ERK, p38, and JNK). Taken together, the immune-enhancing effects of 30% ethanol extract of PBE in vitro were identified. These findings can be used as data for the development of edible insect-based functional foods that improve immune function.
- Subjects
MACROPHAGES; EDIBLE insects; LARVAE; FUNCTIONAL foods; NITRIC oxide
- Publication
International Journal of Industrial Entomology & Biomaterials, 2022, Vol 45, Issue 2, p108
- ISSN
1598-3579
- Publication type
Article
- DOI
10.7852/ijie.2022.45.2.108