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- Title
Hepatitis C virus-related mixed cryoglobulinemic endocapillary proliferative glomerulonephritis and B-cell non-Hodgkin lymphoma: a case report and literature review.
- Authors
ZHAO, L.-J.; CHEN, F.; LI, J.-G.; YIN, R.; ZHANG, X.-H.; HUANG, S.-M.; LIU, F.
- Abstract
OBJECTIVE: Chronic HCV (hepatitis C virus) infection is recognized as the major cause of mixed cryoglobulinemia. Cryo-globulins continually precipitate and form deposits on the vascular endothelium of small to medium-sized blood vessels, which may progress to vasculitic syndrome. CASE REPORT: A 44-year-old female patient with chronic HCV infection presented with pur-puras, edema and proteinuria. Her renal findings included microscopic hematuria, moderate proteinuria and endocapillary proliferative glomeru-lonephritis (EnPGN) on renal biopsy. Serum cryoglobulins comprised mixed monoclonal cryoglobulins characterized by IgM kappa. The serum protein electrophoresis revealed a monoclonal M protein (9.0%). CD19 and CD20-positive B-cell oligo-monoclonal expansion in the bone marrow was revealed. Rapid relief of the clinical symptoms, the disappearance of proteinuria and a sharp decrease in the HCV viral load were observed in our case after one year of interferon therapy. CONCLUSIONS: HCV infection-associated ex-trahepatic manifestations are diverse, which may lead to misdiagnosis. This is the first report of HCV-associated cryoglobulinemic EnPGN and B-NHL, which rapidly responded to interferon.
- Subjects
HEPATITIS C virus; CRYOGLOBULINEMIA
- Publication
European Review for Medical & Pharmacological Sciences, 2015, Vol 19, Issue 16, p3050
- ISSN
1128-3602
- Publication type
Case Study