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- Title
Ara h 2 and Ara h 6 sensitization predicts peanut allergy in Mediterranean pediatric patients.
- Authors
Agabriel, Chantal; Ghazouani, Ouafeh; Birnbaum, Joëlle; Liabeuf, Valérie; Porri, Françoise; Gouitaa, Marion; Cleach, Isabelle; Grob, Jean‐Jacques; Bongrand, Pierre; Sarles, Jacques; Vitte, Joana
- Abstract
Background Peanut allergy ( PA) management was improved by the introduction of molecular allergology, but guidelines for Mediterranean patients are lacking. We aimed at evaluating peanut component-resolved diagnosis as a diagnostic and prognostic tool in children from Southern France. Methods In 181 pediatric patients, PA diagnosis was founded on medical history, skin prick testing, serum-specific IgE to Arachis hypogea extract and components, Pru p 4, and plant carbohydrates, and oral food challenge. Allergen microarray was also performed in 68 of these patients. Results In peanut-allergic children (n = 117), IgE to Ara h 6 were most prevalent (64%), followed by Ara h 2 (63%), Ara h 1 (60%), and Ara h 9 (52%). Ara h 6 was the best predictor of PA. The second best predictor was the ratio of Ara h 2 IgE to peanut IgE (cutoff 0.113). Persistent childhood PA was associated with complex molecular profiles. Comparison of singleplex and microarray results showed poor concordance for Ara h 2 and Ara h 9. Conclusion Ara h 6 and Ara h 2 are the best predictors of PA at diagnosis in Mediterranean pediatric patients. Ara h 1, Ara h 8, and molecular complexity are associated with PA persistence.
- Subjects
FRANCE; PEANUT allergy; PATIENT compliance; IMMUNOGLOBULIN E; IMMUNOLOGIC diseases
- Publication
Pediatric Allergy & Immunology, 2014, Vol 25, Issue 7, p662
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12299