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- Title
YAP and TAZ Mediators at the Crossroad between Metabolic and Cellular Reprogramming.
- Authors
Di Benedetto, Giorgia; Parisi, Silvia; Russo, Tommaso; Passaro, Fabiana; Fiume, Giuseppe; Palmieri, Camillo; Renna, Maurizio; D'Agostino, Massimo
- Abstract
Cell reprogramming can either refer to a direct conversion of a specialized cell into another or to a reversal of a somatic cell into an induced pluripotent stem cell (iPSC). It implies a peculiar modification of the epigenetic asset and gene regulatory networks needed for a new cell, to better fit the new phenotype of the incoming cell type. Cellular reprogramming also implies a metabolic rearrangement, similar to that observed upon tumorigenesis, with a transition from oxidative phosphorylation to aerobic glycolysis. The induction of a reprogramming process requires a nexus of signaling pathways, mixing a range of local and systemic information, and accumulating evidence points to the crucial role exerted by the Hippo pathway components Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ). In this review, we will first provide a synopsis of the Hippo pathway and its function during reprogramming and tissue regeneration, then we introduce the latest knowledge on the interplay between YAP/TAZ and metabolism and, finally, we discuss the possible role of YAP/TAZ in the orchestration of the metabolic switch upon cellular reprogramming.
- Subjects
INDUCED pluripotent stem cells; GENE regulatory networks; SOMATIC cells; OXIDATIVE phosphorylation; PHENOTYPES; GLYCOLYSIS
- Publication
Metabolites (2218-1989), 2021, Vol 11, Issue 3, p154
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo11030154