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- Title
ILB ® Attenuates Clinical Symptoms and Serum Biomarkers of Oxidative/Nitrosative Stress and Mitochondrial Dysfunction in Patients with Amyotrophic Lateral Sclerosis.
- Authors
Lazzarino, Giacomo; Mangione, Renata; Belli, Antonio; Di Pietro, Valentina; Nagy, Zsuzsanna; Barnes, Nicholas M.; Bruce, Lars; Ropero, Bernardo M.; Persson, Lennart I.; Manca, Benedetta; Saab, Miriam Wissam; Amorini, Angela M.; Tavazzi, Barbara; Lazzarino, Giuseppe; Logan, Ann
- Abstract
Oxidative/nitrosative stress and mitochondrial dysfunction is a hallmark of amyotrophic lateral sclerosis (ALS), an invariably fatal progressive neurodegenerative disease. Here, as an exploratory arm of a phase II clinical trial (EudraCT Number 2017-005065-47), we used high performance liquid chromatography(HPLC) to investigate changes in the metabolic profiles of serum from ALS patients treated weekly for 4 weeks with a repeated sub-cutaneous dose of 1 mg/kg of a proprietary low molecular weight dextran sulphate, called ILB®. A significant normalization of the serum levels of several key metabolites was observed over the treatment period, including N-acetylaspartate (NAA), oxypurines, biomarkers of oxidative/nitrosative stress and antioxidants. An improved serum metabolic profile was accompanied by significant amelioration of the patients' clinical conditions, indicating a response to ILB® treatment that appears to be mediated by improvement of tissue bioenergetics, decrease of oxidative/nitrosative stress and attenuation of (neuro)inflammatory processes.
- Subjects
AMYOTROPHIC lateral sclerosis; HIGH performance liquid chromatography; MOTOR neuron diseases; MITOCHONDRIA; DISEASE progression; NEURODEGENERATION; BIOMARKERS
- Publication
Journal of Personalized Medicine, 2021, Vol 11, Issue 8, p794
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm11080794