We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis of glycosylated β-amino alcohols as promising antitubercular agent.
- Authors
Singh, Archana; Agrahari, Anand K.; Singh, Mala; Tripathi, Vishwa Deepak; Tiwari, Vinod K.
- Abstract
A series of novel glycosylaled β-amino alcohols has been synthesised via TBAB/NEt -catalyzed ring opening of 3 oxirane ring in D-glucose-derived 5,6-anhydro-3-O-benzyl-1,2-O-isoprpylidene-α-D-glucofuranose with different primary- and secondary amines including aliphatic, aromatic, heterocyclic, and glycosyl amine. However, the oxirane ring opening in the above anhydroglucose derivative with diamines led to the formation of respective diglycosylated N1,Nn-diaminoalcohols in excellent yield. The method is straight forward, economic, high-yielding and easy to perform in gram scale. The synthesised glycosylaled α-aminoalcohols may serve as interesting scaffold to develop new chemotherapeutic agents.
- Subjects
AMINO alcohols; ANTITUBERCULAR agents; CARBOHYDRATES
- Publication
Trends in Carbohydrate Research, 2017, Vol 9, Issue 4, p28
- ISSN
0975-0304
- Publication type
Article