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- Title
Acquired idiopathic generalized anhidrosis following pembrolizumab treatment.
- Authors
Furuta, K.; Horiguchi, A.; Nakagawa, Y.; Kambe, N.; Kogame, T.
- Abstract
Thus, the sole manifestation of AIGA as irAE might be overlooked in other patients as anhidrosis rarely causes skin manifestations and patients may not consider it a disease that requires treatment. Recent studies revealed that 60%-100% of patients with AIGA had elevation of serum CEA level, and that this correlates with disease activity.6 Detection of AIGA in our case was helped by repetitive CEA measurements because of the patient's colorectal malignancy. Acquired idiopathic generalized anhidrosis (AIGA) causes a type of heat intolerance that can be life-threatening but is often overlooked.1 We report a patient who developed AIGA possibly as an immune-related adverse event (irAE) of pembrolizumab.
- Subjects
THYROIDITIS; PEMBROLIZUMAB; IMMUNE checkpoint inhibitors
- Publication
Clinical & Experimental Dermatology, 2022, Vol 47, Issue 2, p463
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/ced.14967