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- Title
Intrathyroidal CD4+ T Lymphocytes Express High Levels of Fas and CD4+CD8+ Macrophages/Dendritic Cells Express Fas Ligand in Autoimmune Thyroid Disease.
- Authors
Yukiyo Nakamura; Mikio Watanabe; Fumio Matsuzuka; Hayato Maruoka; Akira Miyauchi; Yoshinori Iwatani
- Abstract
In autoimmune thyroid disease (AITD), the proportion of CD4 lymphocytes is lower in the thyroid than in theperipheral blood. We examined both Fas and Fas ligand (FasL) expression in lymphocyte subsets and nonlymphoidmononuclear cells including monocytes, macrophages, and dendritic cells (M/DCs) in both peripheralblood and thyroid specimens from 11 patients with Graves' disease and 1 with Hashimoto's disease bythree-color flow cytometry. Proportions and intensities of Fas expression were increased in CD4 single-positive(SP) (CD4+CD8-), CD8 SP (CD8+CD4-), and CD4+CD8+ double-positive (DP) lymphocytes in AITD thyroidscompared to those in blood, and were much higher in CD4+ (CD4 SP and DP) lymphocytes than in CD8SP lymphocytes in the thyroid. In the blood, most M/DCs expressed only CD4, but approximately 60% ofM/DCs expressed both CD4 and CD8 in AITD thyroid. The proportion of DP M/DCs expressing FasL washigher in thyroid than in blood; proportion and intensity of FasL expression were much higher in DP M/DCsthan in CD4 SP and CD8 SP M/DCs in the thyroid. These data indicate that increased Fas expression in intrathyroidalCD4+ T lymphocytes may be the cause of CD4 lymphocyte reduction in AITD thyroid, and thatintrathyroid DP M/DCs with high FasL expression may be related to the reduction in AITD.
- Publication
Thyroid, 2004, Vol 14, Issue 10, p819
- ISSN
1050-7256
- Publication type
Article