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- Title
Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors.
- Authors
Gui-Zhen Zhang; Tian-Fang Li; Shuang-Yin Han; Zhang, Gui-Zhen; Li, Tian-Fang; Han, Shuang-Yin
- Abstract
Significant progresses have been made in adoptive cell therapy with CAR-T cells for cancers, especially for hematological malignancies. However, the treatment of solid tumors still poses a tremendous challenge and remains an unmet medical need. Several factors are held responsible for the inadequate responses: tumor heterogeneity, inefficient homing of T cells to tumor tissues, immunosuppressive microenvironment and the shortage of specific antigens shortage. Mesothelin is a cell-surface glycoprotein highly expressed in many types of solid tumors. As such, it has attracted much attention as a molecular target in cancer immunotherapy. Here, we delineate the barriers imposed by solid tumors on CARs, outline the rationale of mesothelin as a target for immunotherapy, summarize the preclinical and clinical results of mesothelin-targeted therapies, and extrapolate the expected results of CAR-T cells directed against mesothelin for solid tumors.
- Subjects
CELLULAR therapy; DRUG target; TUMORS; HEMATOLOGIC malignancies; T cells
- Publication
Archives of Medical Science, 2021, Vol 17, Issue 5, p1213
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms.2019.84888