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- Title
Establishment of an in vitro evaluation system for drug-coated balloons.
- Authors
Kaule, S.; Petersen, S.; Minrath, I.; Schmitz, K.-P.; Sternberg, K.
- Abstract
The drug-coated balloon (DCB) is an emerging device in percutaneous coronary intervention, which has shown promising results by means of an efficient local release of paclitaxel (PTX) without the need of an implant remaining in the patient's body. Safety and efficacy of DCB have been already proven in clinical trials for the treatment of in-stent restenosis and complex coronary de novo lesion subsets, such as small vessel diseases, diabe-tes, and diffuse lesions, where stents obtain suboptimal results. However, there is only very few literature data about coating and drug delivery characteristics. In this context, we set up an in vitro evaluation system for DCB including determination of coating morphology, coating thickness, mechanical performance, drug loss and drug application as well as particle release during simulated use. Exemplary data of drug delivery characteristics of an urea-based DCB are provided within the present paper
- Publication
Biomedical Engineering / Biomedizinische Technik, 2013, Vol 58, p1
- ISSN
0013-5585
- Publication type
Article
- DOI
10.1515/bmt-2013-4083