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- Title
Treatment With Subantimicrobial Dose Doxycycline Improves the Efficacy of Scaling and Root Planing in Patients With Adult Periodontitis.
- Authors
Caton, Jack G.; Ciancio, Sebastian G.; Blieden, Timothy M.; Bradshaw, Mark; Crout, Richard J.; Hefti, Arthur F.; Massaro, Joseph M.; Polson, Alan M.; Thomas, John; Walker, Clay
- Abstract
Background: In a previous study, subantimicrobial dose doxycycline (SDD) significantly improved clinical parameters associated with periodontal health in patients with adult periodontitis (AP) when used as an adjunct to a maintenance schedule of supragingival scaling and dental prophylaxis. In this double-blind, placebo-controlled, parallel group, multicenter study, the efficacy and safety of $DD were evaluated in conjunction with scaling and root planing {SRP) in patients with AP. Methods: Patients (n = 190) received SRP at the baseline visit and were randomized to receive either SDD 20 mg bid or placebo bid for 9 months. Efficacy parameters included the per-patient mean changes in clinical attachment level (CAL) and probing depth (PD) from baseline, the per-patient percentages of tooth sites with attachment loss (AL) ≥2 mm and ≥3 mm from baseline, and the per-patient percentage of tooth sites with bleeding on probing. Prior to analysis, tooth sites were stratified by the degree of disease severity evident at baseline Results: In tooth sites with mild to moderate disease and severe disease (n = 183, intent-to-treat population), improvements in CAL and PD were significantly greater with adjunctive SDD than with adjunctive placebo at 3, 6, and 9 months (all P <0.05). In tooth sites with severe disease, the per-patient percentage of sites with AL ≥2 mm from baseline to month 9 was significantly lower with adjunctive SDD than with adjunctive placebo (P <0.05). Improvements in clinical outcomes occurred without detrimental shifts in the normal periodontal flora or the acquisition of doxycycline resistance or multiantibiotic resistance. SDD was well tolerated, with a low incidence of discontinuations due to adverse events. Conclusions: The adjunctive use of SDD with SRP is more effective than SRP alone and may represent a new approach in the long term management of AP.
- Subjects
ANTI-infective agents; TOOTH root planing; PERIODONTITIS; DRUG efficacy; PERIODONTAL disease
- Publication
Journal of Periodontology, 2000, Vol 71, Issue 4, p521
- ISSN
0022-3492
- Publication type
Article
- DOI
10.1902/jop.2000.71.4.521