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- Title
Human Herpesvirus 6 Latent Infection in Patients With Glioma.
- Authors
Chi, Jing; Gu, Bin; Zhang, Chun; Peng, Guangyong; Zhou, Feng; Chen, Yun; Zhang, Guofeng; Guo, Yidi; Guo, Dandan; Qin, Jian; Wang, Jinfeng; Li, Lingyun; Wang, Fang; Liu, Genyan; Xie, Fangyi; Feng, Dongju; Zhou, Hong; Huang, Xingxu; Lu, Shiqiang; Liu, Yingxia
- Abstract
The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor α, and transforming growth factor β (TGF-β) were detected in the cyst fluid specimens from HHV-6–positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF-β production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.
- Subjects
HUMAN herpesvirus-6 infections; GLIOMAS; ETIOLOGY of diseases; DNA; TISSUE analysis; TUMOR necrosis factors; TRANSFORMING growth factors
- Publication
Journal of Infectious Diseases, 2012, Vol 206, Issue 9, p1394
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jis513